{"id":31,"date":"2026-10-20T01:11:05","date_gmt":"2026-10-20T01:11:05","guid":{"rendered":"https:\/\/conkwest.com\/?page_id=31"},"modified":"2026-10-20T01:43:06","modified_gmt":"2026-10-20T01:43:06","slug":"licensing","status":"publish","type":"page","link":"https:\/\/conkwest.com\/?page_id=31","title":{"rendered":"LICENSING"},"content":{"rendered":"\n
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Licensing<\/h1>\n<\/div>\n\n\n\n
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\n\t\t\tIn addition to its promising therapeutic capabilities, Conkwest\u2019s\n\t\t\tNatural Killer (NK) cell line<\/a>\n\t\t\tis a versatile product with broad non-therapeutic applications.\n\t\t<\/p>\n\n\n\n

\n\t\t\tEnhanced versions of the parent NK-92 cell line provide a valuable platform for testing antibody-dependent cellular cytotoxicity (ADCC) responses in vitro.\n\t\t<\/p>\n\n\n\n

Role of NK Cells in ADCC<\/h2>\n\n\n\n
\"Antibody<\/figure>\n\n\n\n

\n\t\t\tAntibody-dependent cellular cytotoxicity (ADCC) is one of the most potent molecular mechanisms used by the immune system to eliminate tumor cells.\n\t\t<\/p>\n\n\n\n

\n\t\t\tSeveral prominent therapeutic anti-tumor antibodies, such as Rituxan\u00ae and Herceptin\u00ae, promote ADCC to induce tumor cell death. NK cells are the key immune cells that promote the ADCC response.\n\t\t<\/p>\n\n\n\n

ADCC Assays Challenges<\/h2>\n\n\n\n

\n\t\t\tNumerous pharmaceutical and biotechnology companies are developing and testing therapeutic anti-tumor antibodies to treat cancer. A reproducible and low-cost ADCC assay to measure the potency of these antibody drug products is greatly needed.\n\t\t<\/p>\n\n\n\n

\n\t\t\tCurrently, the available in vitro ADCC assay involves acquiring and culturing primary NK cells derived from volunteer human donors, a process that can be costly and inconsistent.\n\t\t<\/p>\n\n\n\n

NK-92 in ADCC Assays<\/h2>\n\n\n\n
\"NK-92<\/figure>\n\n\n\n

\n\t\t\tConkwest\u2019s proprietary NK-92 cell line has been transduced to express the two major variants of the CD16 receptor.\n\t\t<\/p>\n\n\n\n

\n\t\t\tTwo versions of the NK-92.CD16 cell line have been established: one expresses the high affinity receptor and the other expresses the low affinity receptor.\n\t\t<\/p>\n\n\n\n

The NK-92 Advantage<\/h2>\n\n\n\n

\n\t\t\tThe NK-92 cell line has significant advantages over other available NK-like cells for use in functional assays. The major advantage is NK-92\u2019s high cytolytic responsiveness toward a wide variety of tumor target cells.\n\t\t<\/p>\n\n\n\n

Assay Applications<\/h2>\n\n\n\n
\"Assay<\/figure>\n\n\n\n

\n\t\t\tNK-92.CD16 cells provide a platform for testing ADCC responses in-vitro and offer potential applications including:\n\t\t<\/p>\n\n\n\n