{"id":27,"date":"2026-10-20T01:10:05","date_gmt":"2026-10-20T01:10:05","guid":{"rendered":"https:\/\/conkwest.com\/?page_id=27"},"modified":"2026-10-20T01:40:03","modified_gmt":"2026-10-20T01:40:03","slug":"product-pipeline","status":"publish","type":"page","link":"https:\/\/conkwest.com\/?page_id=27","title":{"rendered":"PRODUCT PIPELINE"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull cw-page is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group alignfull cw-page-title has-global-padding is-layout-constrained wp-container-core-group-is-layout-c3b8a10d wp-block-group-is-layout-constrained\">\n<h1 id=\"product-pipeline\" class=\"wp-block-heading\">Product Pipeline<\/h1>\n<\/div>\n\n\n\n<div class=\"wp-block-group cw-page-inner has-global-padding is-layout-constrained wp-container-core-group-is-layout-c3b8a10d wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns cw-inside-columns is-layout-flex wp-container-core-columns-is-layout-49329d62 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column cw-icon-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"https:\/\/web.archive.org\/web\/20150228083638im_\/http:\/\/www.conkwest.com\/wp-content\/themes\/conkwest\/images\/logo-icon-2.png\" alt=\"Conkwest\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column cw-content is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"wp-block-paragraph\">\n\t\t\t\t\tConkwest\u2019s portfolio of products includes the original\n\t\t\t\t\t<a href=\"\/nk-92\/\">Neukoplast<\/a>\n\t\t\t\t\tcell line, currently in clinical trials, and several genetically modified lines. These modifications impart additional cancer killing features, each geared towards specific cancer applications.\n\t\t\t\t<\/p>\n\n\n\n<figure class=\"wp-block-image size-full cw-pipeline\"><img decoding=\"async\" src=\"https:\/\/web.archive.org\/web\/20150228083638im_\/http:\/\/www.conkwest.com\/wp-content\/uploads\/2010\/07\/pipeline.png\" alt=\"Conkwest Product Pipeline\"\/><\/figure>\n\n\n\n<h2 id=\"neukoplast\" class=\"wp-block-heading\">Neukoplast<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\n\t\t\t\t\tThe most advanced in clinical development, Neukoplast is the native cell-line, which has been used in patients with leukemia, lymphoma, melanoma and cancers of the lung, and kidney.\n\t\t\t\t<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\n\t\t\t\t\tTwo phase I clinical trials with Neukoplast have been completed and two more Phase I trials are ongoing, with a Phase II study in Merkel Cell Carcinoma also in development. To date, Neukoplast has consistently demonstrated promising clinical activity in addition to an excellent safety profile.\n\t\t\t\t<\/p>\n\n\n\n<h2 id=\"car-neukoplast\" class=\"wp-block-heading\">CAR-Neukoplast<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\n\t\t\t\t\tCAR-Neukoplast is a family of engineered Neukoplast cell lines specifically designed to target proteins found only on certain cancers. These targeting modifications enhance Neukoplast\u2019s killing capacity against some of the most resistant cancer types.\n\t\t\t\t<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\n\t\t\t\t\tOf the CAR-Neukoplast family of products, the most advanced cell line in development expresses a receptor for ErbB2\/HER2, commonly found on cancers of the breast, ovary, prostate, and glioblastoma.\n\t\t\t\t<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\n\t\t\t\t\tNK-92.ErbB2\/HER2 is currently in preclinical development in the\n\t\t\t\t\t<a href=\"\/partnerships-collaborations\/\">Retarget-IT<\/a>\n\t\t\t\t\tprogram with a collaborator in Frankfurt, Germany.\n\t\t\t\t<\/p>\n\n\n\n<h2 id=\"cd16-neukoplast\" class=\"wp-block-heading\">CD16-Neukoplast<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\n\t\t\t\t\tCD16-Neukoplast is an engineered Neukoplast cell line that is able to bind directly to antibodies such as Herceptin\u00ae, Rituxan\u00ae, Erbitux\u00ae, as well as many other, markedly enhancing their cancer killing effects.\n\t\t\t\t<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\n\t\t\t\t\tApproximately half of all cancer patients receiving antibody therapies do not optimally utilize the critical ADCC pathway to rid the body of cancer.\n\t\t\t\t<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\n\t\t\t\t\tCD16-Neukoplast exclusively possesses the high affinity genotype to most effectively work in concert with antibody therapies such as Rituxan\u00ae to eliminate cancer.\n\t\t\t\t<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\n\t\t\t\t\tPresently, CD16-Neukoplast is undergoing\n\t\t\t\t\t<a href=\"\/partnerships-collaborations\/\">preclinical evaluation<\/a>\n\t\t\t\t\tto determine its utility when combined with anti-CD123 to target leukemic stem cells.\n\t\t\t\t<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\n\t\t\t\t\tIn addition to therapeutic applications, CD16-Neukoplast is becoming increasingly recognized as a preferred\n\t\t\t\t\t<a href=\"\/licensing\/\">cytotoxicity testing tool<\/a>.\n\t\t\t\t<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Product Pipeline Conkwest\u2019s portfolio of products inclu [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"no-title","meta":{"_gspb_post_css":"","footnotes":""},"class_list":["post-27","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/conkwest.com\/index.php?rest_route=\/wp\/v2\/pages\/27","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/conkwest.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/conkwest.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/conkwest.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/conkwest.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=27"}],"version-history":[{"count":2,"href":"https:\/\/conkwest.com\/index.php?rest_route=\/wp\/v2\/pages\/27\/revisions"}],"predecessor-version":[{"id":46,"href":"https:\/\/conkwest.com\/index.php?rest_route=\/wp\/v2\/pages\/27\/revisions\/46"}],"wp:attachment":[{"href":"https:\/\/conkwest.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=27"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}